Search results for "negative predictive value"

showing 5 items of 5 documents

Prediction of type 2 diabetes mellitus based on nutrition data

2021

Abstract Numerous predictive models for the risk of type 2 diabetes mellitus (T2DM) exist, but a minority of them has implemented nutrition data so far, even though the significant effect of nutrition on the pathogenesis, prevention and management of T2DM has been established. Thus, in the present study, we aimed to build a predictive model for the risk of T2DM that incorporates nutrition data and calculates its predictive performance. We analysed cross-sectional data from 1591 individuals from the population-based Cooperative Health Research in the Region of Augsburg (KORA) FF4 study (2013–14) and used a bootstrap enhanced elastic net penalised multivariate regression method in order to bu…

Elastic net regularizationFood intakeMultivariate statistics24HFL 24-h food listEndocrinology Diabetes and MetabolismPopulation030209 endocrinology & metabolismType 2 diabetesLogistic regression03 medical and health sciences0302 clinical medicinePredictive Value of TestsRisk FactorsElastic net regressionPrediction modelGermanyStatisticsmedicineHumans030212 general & internal medicineeducationNutritionMathematicseducation.field_of_studyNutrition and DieteticsReceiver operating characteristicDietary Surveys and Nutritional EpidemiologyType 2 Diabetes MellitusType 2 diabetesT2DM type 2 diabetes mellitusmedicine.diseasePPV positive predictive valueDietROC receiver operating characteristicCross-Sectional StudiesNPV negative predictive valueDiabetes Mellitus Type 2ROC CurveKORA Cooperative Health Research in the Region of Augsburg24hfl 24-h Food List ; Elastic Net Regression ; Kora Cooperative Health Research In The Region Of Augsburg ; Npv Negative Predictive Value ; Nutrition ; Ppv Positive Predictive Value ; Prediction Model ; Roc Receiver Operating Characteristic ; T2dmResearch ArticleFood ScienceJournal of Nutritional Science
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Determining a healthy reference range and factors potentially influencing PRO-C3 – A biomarker of liver fibrosis

2021

Background & Aims Progressive fibrosis has been identified as the major predictor of mortality in patients with non-alcoholic fatty liver disease (NAFLD). Several biomarkers are currently being evaluated for their ability to substitute the liver biopsy as the reference standard. Recent clinical studies in NAFLD/NASH patients support the utility of PRO-C3, a marker of type III collagen formation, as a marker for the degree of fibrosis, disease activity, and effect of treatment. Here we establish the healthy reference range, optimal sample handling conditions for both short- and long-term serum storage, and robustness for the PRO-C3 assay. Methods PRO-C3 was measured in 269 healthy volunteers…

NASH-CRN NASH Clinical Research NetworkBiopsyDiseaseAST aspartate aminotransferaseRC799-869Ethnic groupsGastroenterologyNIMBLE Non-Invasive Biomarkers of Metabolic Liver Disease (consortium)FibrosisImmunology and AllergyBody mass indexmedicine.diagnostic_testFatty liverNAS NAFLD Activity ScoreGastroenterologyDiseases of the digestive system. GastroenterologyHospitalsNPV negative predictive valueLiver biopsyBiomarker (medicine)Research Articlemedicine.medical_specialtyNAFLD non-alcoholic fatty liver diseaseADAM A Disintegrin and MetalloproteasesNASH non-alcoholic steatohepatitisReference rangeReference valuesAUROC area under the receiver operating characteristics curveInternal medicineALT alanine aminotransferaseBiopsyInternal MedicinemedicineHumansFIB-4 fibrosis-4Healthy volunteersHepatologyALP alkaline phosphatasebusiness.industryCLSI Clinical and Laboratory Standards InstituteT2DM type 2 diabetes mellitusELF™ test Enhanced Liver Fibrosis testmedicine.diseaseLITMUS Liver Investigation: Testing Marker Utility in Steatohepatitis (consortium)Collagen type IIIFibrosisPPV positive predictive valueReference standardsbusinessBody mass indexBiomarkersNon-alcoholic fatty liver disease
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THE INTERPRETAZION OF DIAGNOSTIC TEST: A PRIMER OF ALLERGIST. PRICIPLES OF EVIDENCE BASED MEDICINE TO OBTAIN A PRECISE DIAGNOSIS

2008

Negative predictive value (NPV)Lkelihood ratio negative (LR-)SensitivitySettore MED/09 - Medicina InternaLkelihood ratio positive (LR+)SpecificityEosinophilAsthmaPositive predictive value (PPV)Rhinitis
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Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project-Global Strategy Protocol.

2022

Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate t…

Settore INF/01 - Informaticaintestinal biopsypoint-of-care testanti-transglutaminaseguidelinesnegative predictive valueartificial intelligenceESPGHANmucosal depositsPediatricscoeliac diseaseSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Pediatric reports
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Prediction of N0 Irradiated Rectal Cancer Comparing MRI Before and After Preoperative Chemoradiotherapy

2017

Background: The prediction of lymph node status using MRI has an impact on the management of rectal cancer, both before and after preoperative chemoradiotherapy. Objective: The purpose of this study was to maximize the negative predictive value and sensitivity of mesorectal lymph node imaging after chemoradiotherapy because postchemoradiation node-negative patients may be treated with rectum-sparing approaches. Design: This was a retrospective study. Settings: The study was conducted at a tertiary care hospital. Patients: Sixty-four patients with locally advanced rectal cancer who underwent preoperative chemoradiotherapy and MRI for staging and the assessment of response were evaluated. Mai…

medicine.medical_specialtyStagingColorectal cancerNegative predictive valuePreoperative care03 medical and health sciences0302 clinical medicineMagnetic resonance imagingmedicineRectal cancer; Chemoradiotherapy; Lymph node; Staging; Magnetic resonance imaging; Negative predictive value.Rectal cancerLymph nodeMesorectalmedicine.diagnostic_testbusiness.industryGastroenterologyMagnetic resonance imagingGeneral MedicineChemoradiotherapymedicine.diseasemedicine.anatomical_structure030220 oncology & carcinogenesisPredictive value of testsAdenocarcinoma030211 gastroenterology & hepatologyLymph nodeRadiologybusinessChemoradiotherapy
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